Effects of big dynorphin (Big Dyn), a prodynorphin-derived peptide consisting of dynorphin A (Dyn A) and dynorphin B (Dyn B) on memory function, anxiety, and locomotor activity were studied in mice ...
The orexin (Orx) system plays a critical role in drug addiction and reward-related behaviors. The dynorphin (Dyn) system promotes depressive-like behavior and plays a key role in the aversive effects ...
One of the main features of Alzheimer's disease is that the β-amyloid peptide, a molecule found inside neurons that has many diverse functions, begins to fold incorrectly and accumulates. This process ...
A study coordinated by the UAB, based on computer models and human cell cultures, shows that big dynorphin, an endogenous opioid peptide, protects neurons against the cytotoxic effects of β-amyloid ...
Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have identified a neural circuit in the amygdala, the brain’s seat of emotion processing, that gives rise to anxiety. Their insight has revealed ...
Neuroscientists have identified a neural circuit in the amygdala, the brain's seat of emotion processing, that gives rise to anxiety. Their insight has revealed the critical role of a molecule called ...
Relevant for inflammation and chronic pain The new study is published in PNAS and it investigates the interaction between Big Dynorphin and the receptor called Acid-Sensing Ion Channel (ASIC). The ...
Some people's brains may harbor their own built-in defense system against the addictive powers of cocaine. According to new research at The Rockefeller University, a naturally occurring brain opiate ...
Neuroscientists at Cold Spring Harbor Laboratory (CSHL) have identified a neural circuit in the amygdala, the brain’s seat of emotion processing, that gives rise to anxiety. Their insight has revealed ...
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